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doi: 10.3389/fonc.2022.997919 Received 19 July 2022 Accepted 28 November 2022 Published 19 January 2023 Volume 12 - 2022 Edited by Cinzia Domenicotti, Universit di Genova, Italy Reviewed by Barbara Marengo, University of Genoa, Italy

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An intriguing avenue of research is the combination of peptides and nuclear hormones, where the peptide serves to target the latter to specific tissues and intracellular sites of action to minimise adverse off-target tissue effects