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Redness, swelling, itching, or pain at the injection site Black box warning Most GLP-1 agonist drugs carry a serious warning about the risk of thyroid cancer

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Pharmacological inhibition of the PI3K/mTOR pathway abolished such effects, suggesting that the metabolic actions of GLP-1 depend on mTOR activity

Monitoring parameters during dose titration should include assessment of gastrointestinal tolerance at each visit to guide the pace of dose escalation

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