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Peptides 2018;100:4853.ArticlePubMed 108

Introduction Finding a wellness routine that actually works often feels like a balancing act

Although dysfunction of the valves in leg veins is the typical cause of increased venous blood pressure, other factors can also contribute, including obstruction of the veins (eg, by blood clots) and decreased contraction of calf muscles (eg, due to leg immobility)

Their studied mechanisms are complementary: one is examined for vascular and cytoprotective signaling and the other for cytoskeletal and migratory dynamics

While this consensus exercise will use the current review as its primary evidence base, the RAND/UCLA process itself is not included in this publication