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Among the patients who developed gastrointestinal side effects, the number of gut bacteria such as Sutterella , Allisonella , Akkermansia , Bacteroides , and Paraprevotella species was significantly elevated (Bryrup et al., 2019), which may be a possible cause of gastrointestinal discomfort reactions in some patients

This makes retatrutide the first triple-receptor agonist to reach late-stage clinical trials, representing the next step in the evolution of incretin-based metabolic research compounds