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Sources: Bozkurt A, Cakir B, et al

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Related articles and topics: References: StatPearls , StatPearls Publishing, 2025

In pediatric patients with trimethylaminuria (FMO3 deficiency), the use of metronidazole, amoxicillin, and neomycin can partially inhibit the conversion of choline to TMA, with neomycin being the most effective, followed by amoxicillin, and metronidazole being the weakest effective among them

However, owing to its bicyclic backbone structure limitations, an LNA can only spontaneously form A-type hybrid duplexes with target nucleic acid strands