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Genetic factors : Variants in genes like MTHFR or COMT may alter how your body processes B12 and related nutrients

Metformin inhibited proliferation and metastasis of colorectal cancer and presented a synergistic effect on 5-FU

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It also appears in angiogenesis assay models and collagen-synthesis assays

[2] [3] Additionally, because the compound promotes blood vessel formation (angiogenesis), there are theoretical concerns about potential cancer promotion that require further investigation