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This orientation allows it to interact with ROS on both sides, helping stabilize and protect the cell.19 Laboratory studies show that this structural advantage may make astaxanthin 10100 times more potent than vitamin E or beta-carotene in quenching singlet oxygen, one of the most reactive and damaging forms of oxygen in the body.20 40 Because of this positioning, astaxanthin can influence how cells respond to stress, potentially protecting lipids, proteins, and DNA from oxidation.39 In human studies, its effects appear to stem mainly from two biological roles: reducing oxidative and inflammatory stress and supporting mitochondrial health the processes that govern cellular energy and resilience.21 41 These mechanisms appear to underlie many of the outcomes observed in clinical research

SIRTs play important roles by stimulating antioxidant expression, repairing cells damaged by oxidative stress, and preventing cell dysfunction

In view of the recent interest in GLP-1R agonism as a nonalcoholic fatty liver disease treatment, we evaluated liver histology after chronic treatment, showing greater steatosis resolution with exendin-phe1 (Fig