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[6] It can attenuate neuroinflammation and promote neuroprotection in multiple sclerosis , inhibit microglial activation, and may enhance remyelination processes, thereby potentially decreasing relapse rates and neurological damage

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None of these endpoints has been validated against clinical outcomes for GLP-1R agonists specifically, and EVOKE is the cautionary case of how readily a biomarker shift and a clinical result can be conflated