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Reductive carboxylation A process that occurs in some normal and cancer cells whereby -ketoglutarate proceeds 'backwards' through the tricarboxylic acid cycle, being reduced through the consumption of NADPH by isocitrate dehydrogenase in the non-canonical reverse reaction to form citrate

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Data in (A), (C), (D), and (E) represent three independent experiments

Acknowledgements The authors are thankful to Integral University, Lucknow, and Eras Lucknow Medical College and Hospital, Era University, Lucknow for providing their assistance during this work

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