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With retatrutide, Phase 2 trial data (Jastreboff et al., NEJM , 2023) demonstrated mean reductions in body weight of up to approximately 24% over 48 weeks at the highest dose studied

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Curry SJ, Krist AH, Owens DK, Barry MJ, Caughey AB, Davidson KW, et al

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Biomaterials 30, 30503057 (2009)

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Going without food can trigger our body's natural defenses against starvation by slowing our metabolism

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These changes can trigger tension-type headaches or migraines as your brain and cardiovascular system adapt to new hormonal signals

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