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Although there are no data to support this, a pure speculation may be that obesity may be accompanied by changes in the reward circuitries, which increases sensitivity to the effects of this class of anti-obesity drugs over a wider range of compulsive behaviors

The fear of potential long-term complications such as neuropathy, retinopathy, and kidney disease further exacerbates this stress, which frequently results in a clinically significant apprehension regarding complications [116, 117]

Zhao L, Zhou XX, Xie F, Zhang L, Yan HY, Huang J, Zhang C, Zhou FF, Chen J, Zhang L

Neurofibrosarcoma-derived Schwann cells overexpress platelet-derived growth factor (PDGF) receptors and are induced to proliferate by PDGF BB