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Most of the TmGsts were predicted by the WolF PSORT to localize in cytoplasm (9 out of 20 proteins), followed by mitochondria, and nucleus (Fig
The long non-coding RNA lnc-HZ06 maintains the stability of HIF1-SUMO by inhibiting the deSUMOylating enzyme SENP1, thereby forming a positive feedback loop that enhances the ferroptosis process
low T3/T4 reduces their activity *Elevated homocysteine - hypothyroidism raises homocysteine levels, which depletes glutathione and increases cardiovascular oxidative stress A study on thiol-disulfide and glutathione homeostasis in thyroid patients found that "oxidative stress remains a prevailing issue in patients with autoimmune or non-autoimmune hypothyroidism" - confirming that glutathione depletion is a consistent feature across the thyroid disease spectrum, not limited to autoimmune forms
Integrins and matrix-regulation mechanisms. Cell
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