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2 The D 4 R-modulated frontal-cortico-striatal neuron D 4 R is highly expressed in the prefrontal cortex of mammals, including rodents and human and non-human primates, particularly in deep layer neurons (1, 1214)
Genetic predisposition, environmental factors such as infections and stress, disruptions in the gut microbiome, excessive iodine intake, and epigenetic changes have all been implicated in the development of GD

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The kinetics of enzyme-catalyzed reactions with two or more substrates or products