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Disadvantages include less predictable absorption, potential variability between doses, and the need for strict technique (holding the drops under the tongue for 60-90 seconds without swallowing)

If you're heavy, that really puts a challenge on those lymphatic vessels

This cannot be predicted in general terms

However, semaglutide has comprehensively surpassed exenatide in every clinical dimension: weight loss efficacy (approximately 4-5 fold greater), glycemic control (superior in SUSTAIN 3 head-to-head), cardiovascular outcomes (proven superiority vs non-inferiority), dosing convenience (pre-filled pen without reconstitution), and formulation options (oral available)

So, typically, you must take the drugs for the rest of your life to maintain the benefits.