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Read clinical review Clinical Reviews GIP/GLP-1 Dual Agonists: Special-Populations Prescribing Summary Evidence-based prescribing guide for tirzepatide and other GIP/GLP-1 dual agonists in renal impairment, hepatic disease, older adults, adolescents, pregnancy, and heart failure with preserved ejection fraction

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While Glu9 of GLP-1 formed strong and persistent hydrogen bond and van der Waals interactions with R190 2.60 , Y152 1.47 , and to a lesser extent, Y148 1.43 , the polar side chain of Gln3 in oxyntomodulin only formed weak and very transient hydrogen bonds with these residues, and van der Waals interactions only with Y148 1.43 (Movie S1, Supplementary Table 3)