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Patent thickets clusters of secondary patents covering formulations, manufacturing processes, dosing regimens, and metabolites can delay generic entry by years
Fixing a severe problem produces more noticeable results than fine-tuning a system that was already working adequately
Adler, R.R
Symptoms may also become more noticeable after a dose increase because the body is adjusting to a stronger effect
Factor in shipping time, warehouse storage, and delivery delays, and a liquid vial with a 90-day shelf life might arrive with only 50-60 usable days remaining
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