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The primary antibodies used are as follows: P53 (Proteintech, 60283-2-Ig), pSer46-P53 (CST, 2521), FOXO4 (Proteintech, 21535-1-AP), Ki-67 (D3B5) Rabbit mAb (Alexa Fluor 647 Conjugate) (CST, 12075), P21 (CST, 14074), -H2AX (Abcam, ab2254)
Specifically, we do not know what component of GLP-1 effects is attributable not to risk factor modulation, but rather to processes acting directly on the heart
Tina Yi-Jin Hsieh, MD
Metformin is commonly thought to block FXR function through an AMPK-mediated process, resulting in reduced bile acid absorption in the ileum
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