Ive heard of people reporting the worst upper stomach pain imaginable along with persistent nausea, thankfully not my own patients, and thats exactly the symptom cluster we worry about with pancreatitis, he said
By dampening dopamine-driven impulsivity around eating, Wegovy can help reduce cravings for sugar, refined carbohydrates, and calorie dense snacks
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Its defining structural feature is the gamma-glutamyl linkage: the glutamate residue is joined through its side-chain carboxyl rather than the usual alpha-peptide bond, which makes the molecule resistant to most intracellular peptidases and means it is cleaved almost exclusively by gamma-glutamyl transpeptidase at the outer cell surface (Zhang, Forman and Choi, Methods in Enzymology, 2005)
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