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The manufacturer, Eli Lilly, is enrolling patients with type 2 diabetes to compare the effect of retatrutide with semaglutide in adult patients with type 2 diabetes and poor glycemic control with metformin and with or without SGLT2 inhibitors
Antioxidants such as Vitamin E (Tocopherol) or Ferulic Acid boost its protective properties
While these changes typically require extended exposure at high levels, they represent a real risk of excessive or prolonged use
Clin Trials J 1990;27:155-163
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