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That said, GLP-1s are not bad for most people

It passes through the stomach and small intestine undigested, reaching the colon intact, where beneficial gut bacteria ferment it into short-chain fatty acids, primarily propionate and butyrate

403 Additionally, ketone bodies, which constitute only 1520% of the energy supply, are crucial for heart protection because they improve heart failure and hypertrophy and are easily converted to acetyl-CoA for energy

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N Engl J Med 355:22972307 Aithal GP, Thomas JA, Kaye PV et al (2008) Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis