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Pancreas 44 , 799804 (2015)
2019;35(7):e3168
The increased number of GLP-1 + cells indicated that linagliptin treatment resulted in more cells to express detectable GLP-1, which was in agreement with the increased GLP-1 production in these islets (Fig
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The molecular events leading to activation or silencing of glucose-sensitive neurons are surprisingly similar to those of the endocrine pancreas and include neuronal uptake of glucose via GLUT2, conversion to pyruvate (and finally ATP) via glucokinase, and modulation of neuronal firing mediated by changes in K ATP channel activity, cell depolarisation and Ca 2+ influx
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