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The differences observed can be attributed to several factors inherent to real-world studies as compared to RCTs, and future work is needed to further characterize patient profiles most likely to benefit from GLP-1s with findings from both structured and unstructured clinical data modalities
Nonetheless, the pharmacological activation of the GLP-1R is clinically beneficial (179), offering an improved glycaemic control with lower cardiovascular morbidity and without the risk of hypoglycaemia associated with some current anti diabetic drugs (173)
Alternative GLP-1 Protocols When Semaglutide Plateaus Persist If semaglutide alone reaches a stubborn plateau despite dose optimization, PlexusDx offers compounded alternatives that work through different mechanisms
Coordinating these treatments properly can help minimize the risk of adverse interactions and maximize the benefits of both
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