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Research utilizing the Broad Institute's Connectivity Map indicates it influences the expression of over 4,000 genes (~31% of the human genome), shifting gene signatures from a pathological state back to a healthier, regenerative baseline
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Thus, all adjuvant glucose-lowering therapies in type 1 diabetes are used off-label and contrary to local and national guidance [16]
Mounjaro was previously only FDA-approved for use in type 2 diabetics, but doctors were prescribing it off-label for weight loss
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