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[9] Visual disturbances have been reported in patients with Leber hereditary optic neuropathy, and rapid B12 administration may precipitate optic nerve atrophy in this genetically predisposed population, mandating extreme caution or alternative therapy

W.et al (2014)

Some practitioners recommend cycling sermorelin: 3 to 6 months on, 1 to 2 months off

A cool (not ice-cold) shower or a damp compress can help draw the heat out of the tissue

Moreover, it has also been reported that antioxidant supplementation with vitamin C hampers training-induced adaptations in endurance performance (Gomez-Cabrera et al., 2008)