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In immortalised human airway epithelial cell lines (including bronchial epithelial cells) and human alveolar epitheliallike cells, GLP-1 receptor agonists reduced epithelial stress and inflammatory signalling, including downregulation of epithelial-derived cytokines, including IL-33 and thymic stromal lymphopoietin (TSLP), both of which are implicated in epithelialmesenchymal crosstalk and fibroblast recruitment in fibrotic lung disease [66,67,68]

Novo Nordisk spent years developing Rybelsus , the first oral GLP-1 drug, which is FDA-approved for diabetes treatment and can only be prescribed for weight loss off-label

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