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Safety Profile Both medications were generally well tolerated
Unprecedented Weight Loss: Clinical trials show Retatrutide achieving up to 24% body weight reduction in obese patients, surpassing many existing therapies
Contemporary Endocrinology, Conn PM (ed)
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Metformin is an older insulin-sensitizing drug developed in the 1950s, while GLP-1 agonists like semaglutide are newer hormonal therapies that activate specific intestinal receptors
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