One of the by-products of methionine metabolism is homocysteine which, in high serum quantities, has been linked to developmental disorders, learning disabilities, and skeletal deformities, among others.212 Inositol There are serves means by which inositol exerts its effects in the human body
Studies show that NNMT inhibition by 5-amino-1-methylquinolinium significantly reduces nicotinamide metabolism, increases NAM accumulation, improves NAD+ synthesis efficiency by over 30%, and markedly increases mitochondrial ATP production and cellular energy metabolism
Potential for combination therapy In some cases, a combination of NAD+ and B12 injections might be beneficial
For individuals experiencing mild gastrointestinal upset from B12 supplements (uncommon but possible with high doses), taking the supplement with breakfast may improve tolerance
They are not FDA-approved for the indications listed