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The gutgenital tract microbiota interface and immune crosstalk is a recognised concept in womens health, and diabetes is associated with alterations in vaginal microbiota ecology, particularly around menopause transitions

But that same mechanismespecially slower gastric emptying and changes in gut motilityis also part of why GI side effects are so common

doi: 10.1016/j.yebeh.2022.108839 40 ChristiansenCRodbroPLundM

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Strikingly, we find that the disordered FOXO4-DRI binds to the disordered p53 TAD2 and forms a transiently folded complex