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Brannan CI, Perkins AS, Vogel KS, Ratner N, Nordlund ML, Reid SW, et al

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In the context of Retatrutide research, GCGR activation is studied primarily for its energy expenditure effects particularly increased thermogenesis and hepatic fat oxidation which add a distinct and significant metabolic dimension to the GLP-1R and GIPR incretin effects already present in dual agonists like Tirzepatide