Cacciatore, I., et al
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Several meta-analyses suggest a reduced incidence of gestational diabetes with this dosing strategy, but authors emphasize that evidence quality is moderate and that further large-scale randomized trials are needed before universal recommendations can be made.9 24 25 26 Psychiatric research (high-dose, limited evidence) Studies exploring inositol for panic disorder, obsessive-compulsive disorder, or depression have used much higher doses often 12,00018,000mg per day.35 36 37 While some small trials reported symptom improvement, results have been inconsistent, and these doses are far higher than those used for metabolic or reproductive purposes.38 Most reviews do not recommend high-dose inositol for mental health outside of clinical supervision.42 Across contexts, higher doses do not consistently produce stronger effects
Pan et al, in a in vivo study performed with transgenic mice, have shown that chronic treatment with benfotiamine, a thiamine derivate with better bioavailability, enhanced the spatial memory and reduced both amyloid plaque numbers and phosphorylated tau levels, suggesting that this thiamine derivative may be useful in clinical Alzheimers disease treatment, although others thiamine derivatives do not showed the same results ( Table 2 )
Recurrent isolated neonatal hemolytic anemia: think about glutathione synthetase deficiency
