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Histone deacetylases including SIRT1, interact with STAT3 and negatively regulate its transcriptional activity by deacetylating critical lysine residues ( Short peptides are distinctive biomolecules that combine the benefits of traditional small molecules and mature proteins, offering new, more effective therapeutic agents with fewer side effects ( 2+ affinity comparable to that of albumins copper transport sites, forming an in vivo complex, glycyl-L-histidyl-L-lysine-Cu 2+ (GHK-Cu), which enhances its bioavailability (Figure 1A
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Although free radical reactions are necessary for the defense mechanism of cells such as neutrophils and macrophages from immune system cells, overproduction of free radicals results in tissue damage and cell death [3]
PMID: 23428883
Pickart and team have indicated that a treatment course of 100200 mgs of GHK will produce therapeutic actions in humans for wound healing applications, but that even this amount may be overstated [5]
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