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Exposure to ultra-cold temperatures decreases inflammation and promotes physical resilience

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NNMT inhibition preserved nicotinamide substrate pool Reduced nicotinamide methylation conserved S-adenosyl methionine Elevated intracellular NAD+ increased sirtuin pathway activity Adipocyte metabolic shift altered lipid handling in cell models Core Areas of Scientific Investigation NNMT Enzyme Inhibition: NNMT activity is elevated in adipose tissue in obesity models

Complementary Approaches: The selectivity of AOD-9604 allows flexible combination with other interventions