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Removing senescent cells as a therapeutic strategy was first verified by killing cells with high p16 Ink4a expression in INK-ATTAC and p16-3MR transgenic mice, which delayed organ dysfunction and prolonged the lifespan in mice aged both prematurely and naturally [5]
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An important note on NSAIDs: while ibuprofen and similar medications help with pain, some research suggests they may slightly impair bone healing
