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For example, one study showed that although people treated for 68 weeks with semaglutide (2.4 mg/week) lost an average of 18% of their initial body weight, the majority of this weight was regained within a year following discontinuation of treatment (Figure 7)

Mocciaro et al., 2025)

Wegovy is approved for weight management and obesity

The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice

The drug was conceived as a short-term jumpstart, a way to break inertia and establish new eating patterns while the medication provides a window of reduced appetite