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Developed for treating metabolic disease, they are now being investigated as AUD, CUD, and general SUD treatments
GHK-Cu is a charged, hydrophilic molecule
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Binding activates Gq/11 signaling, raises intracellular IP3 and diacylglycerol, triggers calcium release from the endoplasmic reticulum, and drives GH vesicle exocytosis
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