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In Iodine and Selenium deficiency, serotonin is underproduced, which results in irregular digestion and constipation

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The maintenance dose is generally 1500mcg once a month, or at a schedule determined by the physician based on the patient's ongoing clinical needs and blood test results

Trial-Level Safety Signals to Know Pancreatitis Both compound classes (GLP-1 agonists and amylin analogs) have a small but documented pancreatitis signal across the GLP-1 trial database

This is consistent with the approach recommended for anyone following the standard tirzepatide dosing schedule for weight loss