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Similar to priority products, the provisional determination may be granted to either a new medicine or a new indication where no alternative products are registered for the condition or when preliminary data shows that the provisional product constitutes a substantial improvement in safety or efficacy
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MMP-13 (matrix metalloproteinase-13) is involved in cartilage degradation
The reality: Injectables Still set the efficacy ceiling Strongest outcomes + label support Oral drugs Lower efficacy (~1113%) But expand the market significantly Key insight: This is not one oral category Oral semaglutide requires fasting + waiting Orforglipron taken anytime The winner may be the least inconvenient drug, not the most effective The Hidden Problem: Persistence This is the part almost no one talks about: Only ~24.5% of patients remain on therapy at 12 months ~20% switch therapies within a year After stopping: Weight regain 0.8 kg per month Let that sink in
So I then knew for sure it was the Wegovy that caused this." - WasabiArtistic4675 Some reported their palpitations were intermittent but clearly connected to injection days: "Its sporadic and there is certainly a correlation with the medicine because they get worse every time I inject it." - anonymous (deleted user) And a few describe more severe reactions, including episodes of tachycardia or needing hospital care: "My husband increased doses to 2
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