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Caf-noir spots are hyperpigmented patches that have an even darker hue (relative to background skin) than CALMs and are seen in LEOPARD syndrome (Noonan syndrome with multiple lentigines) and the Carney complex
Regular IGF-1 has 70 amino acids, while Long R3 IGF-1 has 83 amino acids due to the addition of 13 amino acids on its N-terminal end
doi: 10.1152/jappl.1999.87.4.1381 160 LeeC
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Many patients attribute cramps to "the medication" without identifying the correctable biochemical cause, and some clinicians dismiss the complaint as a minor nuisance
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