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The ventral pallidum (VP) receives GABAergic inputs from the nucleus accumbens and projects to the mediodorsal thalamic nucleus and prefrontal cortex, forming the cortex-striatum-cortex loop, which regulates motivated behavior and reward evaluation (23)
Inhibition or knockdown of Nrf2 enhanced erastin- or sorafenib-induced ferroptosis in HCC in vitro and in vivo (49)
doi: 10.1038/s41418-020-00691-x 22 FanetHCapuronLCastanonNCalonFVancasselS
This is why the combination of both, known as CagriSema, has shown results that exceed either compound alone
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