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The structure of Tirzepatide extends its half-life to approximately 5 days by introducing -aminoisobutyric acid (Aib) to replace alanine at positions 2 and 13 to prevent DPP-4 degradation, and by covalently binding to a C20 eicosanedioic acid via a Glu-(AEEA-AEEA) linker at position 20 lysine residue, enabling once-weekly dosing
Dosage and frequency determined by severity and patient response
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