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Cell culture and treatments The murine macrophage cell line RAW 264.7 (TIB-71, American Type Culture Collection, Manassas, VA, USA) was cultured at 37C and under 5% CO 2 condition in Dulbeccos modified Eagles medium (DMEM) containing 4.5 g/L glucose, 10% fetal bovine serum (FBS), and 1% penicillinstreptomycin (P/S) mixture

GLP-1 GLP-1 GLP-1 GLP-1 GLP-1 GLP-1 GLP-1 GLP-1 GLP-1 GLP-1 GLP-1-1 GLP-1 GLP-1GLP-1 GLP-1 GLP-1 GLP-13 GLP-1 GLP-1 GLP-1 GLP-1 GLP-1 GLP-13 GLP-13 GLP-1GIPGLP-1 BMI BMI3 GLP-1 GLP-1 6815% GLP-1 GLP-1 GLP-1 120mL 30 GLP-1 GLP-1 GLP-1 GLP-1 2040% GLP-1 GLP-1 2MEN2 18 BMI18.524.9 GLP-1 6822 SNSGLP-1GLP-1 GLP-1 GLP-1 GLP-1 2613 2BMI35 3 GLP-1 3 1 GLP-1 2 3 GLP-1 1 3 GLP-1 GLP-1 GLP-1 1 11 GLP-1 36 GLP-1 1 GLP-1 GLP-1GLP-1 GLP-1 BMI 61 GLP-1

Further studies are now needed to investigate the mechanisms underlying treatment response and to determine whether efficacy differs between patients with suboptimal initial weight loss and those who subsequently experience weight regain, they added

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