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[13] DSS Model Results : Weight loss significantly reduced at day 8 Myeloperoxidase activity (neutrophil marker) dropped 50% Prevented colon weight increase and length decrease IL-6 and IL-12 mRNA expression significantly reduced Histology showed less inflammation, reduced cell damage, fewer inflammatory cells in tissue layers TNBS Model Results (more acute inflammation): Weight loss reduced within 1-2 days post-TNBS Colonic MPO activity decreased 30% Prevented TNBS-induced colon shortening Broad cytokine suppression: IL-1, IL-6, TNF-, IFN- mRNA all reduced KPV didnt affect inflammatory markers in healthy mice
Brown, G
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The critical role of the SLC46A1 encoded transporter in intestinal folate absorption is evident in individuals with an inherited form of folate malnutrition (hereditary folate malabsorption, HFM) that results from pathogenic variants in the SLC46A1 gene
"We put guardrails in place, which still allows the drug in cases where we think they'll be beneficial, but it's not a one-shot-fits-all," Civello said
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