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In the KEYNOTE-119 trial, monotherapeutic pembrolizumab did not significantly improve OS in patients with previously treated metastatic TNBC compared to chemotherapy, which might inform future research of pembrolizumab monotherapy for selected patients, specifically those with PD-L1-enriched tumors, and combinatorial approach might be necessary for the treatment of patients with metastatic TNBC
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Pioglitazone , a thiazolidinedione, directly enhances insulin sensitivity in adipose tissue and muscle but carries risks of weight gain, fluid retention, and bone fractures
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