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The peptides interaction with IGF-binding proteins is diminished by its altered structure, which includes a longer chain and changed binding characteristics
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The initial elution was isocratic with 30% acetonitrile for 2 min, followed by a linear gradient for 15 min up to 100% acetonitrile
While the technology does not yet exist, by narrowing the pharmacological target of drugs to specific dimers involving GHSR1a, it may be possible to significantly reduce side effects while targeting with more precision the culprits involved in the disorder being treated
DOI: 10.1038/s41598-024-66034-9
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