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Brain Sciences , 7
Strategies that deplete GSH, such as using inhibitors like BSO which is inhibitor of -glutamylcysteine synthetase (-GCS) , the rate-limiting enzyme in glutathione (GSH) synthesis or by combining prodrug activation with GSH depletion in nanosystems, have shown promise in overcoming MDR and improving chemotherapy effectiveness [72]
She adds that published medical literature has raised significant concerns about the potential risks associated with the peptide, including rapid changes in moles and pigmented lesions that can make the detection of skin cancer more difficult and increased risk of melanoma
It is recommended to consult a healthcare professional to determine the appropriate dosage based on individual needs
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