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These differences impact each products effectiveness and duration

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Circulating choline is associated with coronary artery stenosis in patients with hypertension: A cross-sectional study of Chinese adults

If you follow the symbol to the fine print you learn that they define this as [items in brackets are added by me and not part of the original research text] allodynia [extreme sensitivity to touch], burning sensation, dysaesthesia [disruption to sense of touch unusual, unpleasant or painful sensations], hyperaesthesia [sensations felt very intensely], pain of skin, paraesthesia [tingling, numbness or pins and needles], sensitive skin, skin burning sensation, skin discomfort, and skin sensitisation

Suppositories require around 15-20 minutes of retention, to ensure maximum absorption