Sci Adv 2023, 9: eade9585
11 Cyclosporine is a calcineurin inhibitor that prevents T cell maturation
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While it is unsurprising that many ALS symptoms are related to signs of copper deficiency, resulting in vascular, antioxidant system and mitochondrial oxidative respiration deficiencies, there are also signs of copper toxicity such as ROS generation and enhanced protein aggregation