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Cao , Gita Sudama, and James D
Abbreviations ALC: Acetyl-l-carnitine DG: Dentate gyrus GFAP: Glial fibrillary acidic protein GSH: Reduced glutathione Kainate: Kainic acid MDA: Malondialdehyde MFS: Mossy fiber sprouting NF-kB: Nuclear factor-kappa B SE: Status epilepticus ROS: Reactive oxygen species SOD: Superoxide dismutase SE: Status epilepticus TLE: Temporal lobe epilepsy TNF-: Tumor necrosis factor- TBA: Thiobarbituric acid TLR4: Toll-like receptor 4 References Afshin-Majd S, Bashiri K, Kiasalari Z, Baluchnejadmojarad T, Sedaghat R, Roghani M (2017) Acetyl-l-carnitine protects dopaminergic nigrostriatal pathway in 6-hydroxydopamine-induced model of Parkinsons disease in the rat
Research done in Turkey found that 92 percent of Hashimotos patients were deficient in vitamin D, and another 2013 study found that low vitamin D levels were associated with higher thyroid antibodies and worse disease prognosis
The compound's small molecular weight (~504 Da) and non-peptide backbone make it unrecognizable to the aminopeptidases and carboxypeptidases that rapidly degrade conventional peptides in the GI tract and bloodstream
The primary mechanism of action involves the activation of telomerase, an enzyme responsible for maintaining and extending telomeresthe protective caps at the ends of chromosomes
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