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The discovery of its biological activity came from an unexpected observation: serum from young donors (age 20-25) could stimulate aged liver tissue to synthesize proteins at a rate characteristic of younger tissue, while serum from older donors (age 60-80) could not

Vasireddi N, Hahamyan H, Salata MJ, Karns M, Calcei JG, Voos JE, et al

There are many reasons, besides pregnancy, that could cause a delayed period

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A PCAC recommendation is not a rule, and a category change would not constitute FDA approval or create blend-level efficacy data