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Eng began a collaboration with Amylin Pharmaceuticals, and in a series of clinical trials, Exendin-4 injected twice daily showed significant efficacy in Type 2 diabetic patients

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The downstream signaling molecule, PI 3-kinase appears to play a role in Ex-4-induced activation of submucosal neurons and the STAT3 inhibitor attenuated, but did not abolish, the calcium response

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